The former Buxtons furniture store in Ditchling Road is to become home to 300 students from across the globe this summer.
It is set to be transformed into the fourth UK college for Kings Education, which also has colleges in Oxford, London and Bournemouth. It also has five US colleges, including New York and Hollywood.
The £5 million conversion project, which is expected to be completed this June, will create almost 60 jobs. It is also estimated to bring £2 million into the city economy.
The first students will arrive this June, with more coming in October once the planned science and arts building in Oxford Place is complete. The college is seeking host families for its new students.
Andrew Green, the director of Kings Education, said: “We are looking forward to opening the doors of our new international college by early summer.
“We are thrilled to take our place within this vibrant and re-energised area of the city and are looking forward to playing an active role within the community.
“Over time, we hope to offer our space to local community groups.
“We are sure that the economic and cultural impact which our international students will have on the community will be positive and long-lasting.”
The education company is currently recruiting pastoral and teaching staff, and have selected Nigel Addison to be Brighton’s principal. He spent more than 20 years at Bellerbys College in Brighton.
For more information, visit the Kings Education Brighton website.